Morphometric Analysis Of Sonic Hedgehog In Non-Alcoholic Fatty Liver And Steatohepatitis Patients By Morphoquant: A Potential Biomarker Of Disease Severity

By 21 June 2023Poster, NASH / NAFLD

Authors: Cindy Serdjebi1, Bastien Lepoivre1, Florine Chandes1, Linda Willis2, Yvon Julé1

1Biocellvia, Marseille, France
2HistologiX, Innovation Building | BioCity Nottingham, Pennyfoot Street, Nottingham, NG1 1GF, United Kingdom

Cindy Serdjebi, R&D Director,

Sonic hedgehog (Shh) is an important pathway activated in non-alcoholic fatty liver diseases and its expression is known to increase along with the severity of non-alcoholic steatohepatitis (NASH). In addition, computer-assisted morphometry previously demonstrated that Shh expression was associated with ballooning degeneration score as well as fibrosis grading. Yet, the use of this immune-histo-chemistry (IHC) has long been ignored in the current general practice and/or in clinical trials. In this study, we have developed a fully automated morphometry software to detect and quantify Shh expression and investigated the interest of measuring the area of active injury in patients’ liver biopsies.