Diet Reversal and Immune Modulation Show Key Role for Liver and Adipose Tissue T Cells in Murine Nonalcoholic Steatohepatitis

By 21 September 2020November 6th, 2020NASH / NAFLD

Mikhaïl A. Van Herck,1,2,3 Luisa Vonghia,1,2,3 Wilhelmus J. Kwanten,1,2,3 Yvon Julé,4
Thomas Vanwolleghem,1,2,3 Didier G. Ebo,3,5 Peter P. Michielsen,1,2,3 Joris G. De Man,1,3
Lucio Gama,6 Benedicte Y. De Winter,1,3 and Sven M. Francque1,2,3

In this article, we show a critical role for differentially active T-cell subsets in visceral adipose tissue and liver in the pathogenesis of nonalcoholic steatohepatitis using multiple interventional experimental approaches in a high-fat highfructose diet mouse model.